4 Supplements You Should Definitely Know AboutTake note of these names.

Store shelves are often stacked with tiny bottles making big claims. Our experts sorted through a dozen buzzed-about supplements to find four that show real promise.

GLUTATHIONE Credited with a plethora of anti-aging and disease-fighting properties, it's been called the mother of all antioxidants. Your body produces its own glutathione, but unless your life is one big Zen fest, it's likely that stress and environmental toxins leach your natural supply, says Pomroy. Shoot for a 500-milligram daily dose.

MELATONIN New non-habit-forming time-release capsules can help you fall and stay asleep by delivering extra melatonin, a sleep hormone your body produces less of as you age. Finding the correct dosage may take trial and error; start with 1 milligram at bedtime and work up to 5 milligrams, if needed, says Susan Hazels Mitmesser, Ph.D.

NITRIC OXIDE

Found in beets, the molecule helps amp up cellular energy and widen arteries, increasing blood flow to your vital organs and lowering blood pressure, says Pomroy. Studies also show nitric oxide may help reduce athletic fatigue, so you can go that extra mile without feeling spent. Try a 1,000-milligram nitric oxide support supplement.

FISH OIL

It's ever-buzzy for good reason: Packed with fatty acids DHA and EPA, the super-nutrient can hike cardiovascular health and help protect brain tissue, and may lower your risk for depression. A daily 1,000-milligram dose (600 mg EPA/400 mg DHA) of fish oil can also help reduce joint aches, says Susan Kleiner, Ph.D.